Pharmacogenetic considerations with dichloroacetate dosing
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چکیده
منابع مشابه
Clinical and economic consequences of pharmacogenetic-guided dosing of warfarin.
Patients using warfarin for oral anticoagulant therapy need to be frequently monitored because of warfarin's narrow therapeutic range and the large variation in dose requirements among patients. Patients receiving the wrong dose have an increased risk of bleeding or thromboembolic events. The required dose is influenced by environmental factors, such as gender, age, diet and concomitant medicat...
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BACKGROUND The clinical utility of genotype-guided (pharmacogenetically based) dosing of warfarin has been tested only in small clinical trials or observational studies, with equivocal results. METHODS We randomly assigned 1015 patients to receive doses of warfarin during the first 5 days of therapy that were determined according to a dosing algorithm that included both clinical variables and...
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Jeffrey Fudin, PharmD, DAIPM, FCCP, FASHP President and Director, Scientific and Clinical Affairs for Remitigate, LLC, Delmar, NY Adjunct Associate Professor of Pharmacy Practice and Pain Management, Albany College of Pharmacy and Health Sciences, Albany, NY Adjunct Associate Professor, Western New England University College of Pharmacy, Springfield, MA Clinical Pharmacy Specialist and Director...
متن کاملConsiderations in methadone dosing for opioid addiction
Introduction: Methadone has been an essential medication in the treatment of opioid addiction worldwide. Aim: To discuss dosing considerations related to different methadone programs. Method: A search was performed the Ovid (all resources) including: Medline, Cochrane, and EMBASE databases using the following terms: methadone dose, methadone optimization, and methadone adequacy. We compared and...
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Optimal dosing and scheduling are among the most important issues being addressed in clinical studies of the taxanes. The results to date indicate that there may not be a single administration schedule that produces optimal antitumor efficacy. Instead, the specific doses of the taxanes relative to each schedule and the overall aggressiveness of the dosing schedule should be considered. There ap...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2016
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs-2015-0012